ESPERAL (disulfiram), alcohol dependence products

High clinical benefit in the management of alcohol dependent patients maintained

• AOTAL, ESPERAL and REVIA are used to maintain abstinence in alcohol-dependent patients in the context of comprehensive management with psychological counselling.

• AOTAL and REVIA are first-line treatments, while ESPERAL is a second-line treatment due to its antabuse effects.

• A meta-analysis failed to show any significant differences between acamprosate and naltrexone in terms of abstinence and relapse.